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Histone H4

Anti-Histone H4 Products
- Anti-Human H4F3 Recombinant Antibody (TAB-336CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- Human Anti-H4F3 Recombinant Antibody (TAB-090CT) (TAB-090CT)
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- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, WB
- Human Anti-H4F3 Recombinant Antibody; scFv Fragment (TAB-090CT-S(P)) (TAB-090CT-S(P))
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- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, WB
- Human Anti-H4F3 Recombinant Antibody; Fab Fragment (TAB-090CT-F(E)) (TAB-090CT-F(E))
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, WB
- Human Anti-H4F3 Antibody, mRNA (TAB-336CL-mRNA)
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- Species Reactivity: Human
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IHC, FC
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IF, ICC, FC, ChIP
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IF, ICC, FC, ChIP
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For Research Use Only. Not For Clinical Use.
Background
The antibodies bind to a human histone protein, such as H2B, H3 or H4 are of use to treat a variety of diseases that may be associated with histones, such as autoimmune disease, atherosclerosis, arthritis, rheumatoid arthritis, edema, sepsis, septic shock, hyperinflammatory disorder, infectious disease, inflammatory disease, immune dysregulatory disorder, GVHD, transplant rejection, atherosclerosis, asthma, a coagulopathy, myocardial ischemia, thrombosis, nephritis, inflammatory liver injury, acute pancreatitis, ischemia-reperfusion injury, stroke, cardiovascular disease, and burn.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.