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IL13RA1
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
Protein class
CD markers, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (monocytes)
Immune cell specificity
Group enriched (neutrophil, myeloid DC, eosinophil, classical monocyte)
Cell line specificity
Cell line enhanced (HDLM-2)
Interaction
Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1.
Molecular function
Receptor
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