+ Filter
Loading...
IL17RC
Anti-IL17RC Recombinant Antibody Products
- Human Anti-IL17RC Antibody, mRNA (TAB-403CL-mRNA)
-
- Species Reactivity: Human
Compare
- Anti-Human IL17RC Recombinant Antibody (TAB-403CL)
-
- Species Reactivity: Human
- Type: Antibody
Compare
More Infomation
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
More Infomation
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
For Research Use Only. Not For Clinical Use.
IL-17C is a cytokine that is involved in inflammatory processes and human disease. IL-17RE is a receptor for IL-17C. The anti-IL-17RE antibodies are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Proximal enterocytes)
Immune cell specificity
Immune cell enhanced (myeloid DC, classical monocyte)
Cell line specificity
Cell line enhanced (ASC diff, ASC TERT1, HSkMC, T-47d)
Interaction
Homodimer; disulfide-linked (PubMed:32187518). Heterodimer with IL17RA (PubMed:16785495, PubMed:18684971). Heterodimerization with IL17RA is independent of the cytoplasmic tail (By similarity). Associates with non-glycosylated IL17RA constitutively (By similarity). Binding of IL17A and IL17F induces association with glycosylated IL17RA (By similarity). Forms complexes with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule (PubMed:32187518, PubMed:28827714). IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex, whereas IL17F homodimer forms predominantly complexes with IL17RC homodimer (PubMed:32187518). IL17A-IL17F forms complexes with IL17RA-IL17RC, but with lower affinity when compared to IL17A homodimer (PubMed:32187518). IL17RC chain cannot distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (PubMed:28827714). Interacts (through SEFIR domain and extended downstream region) with TRAF3IP2/ACT1 (phosphorylated) (PubMed:24120361).
Molecular function
Receptor
More Types Infomation