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Insulin B

Anti-Insulin B Products

Human Anti-Insulin B Recombinant Soluble TCR (clone 20D11) (scTCR-0564YC-S(P))
- Epitope: SHLVEALYLVCGEEG
- MHC: HLA-DQA1*03:01/DQB1*03:02
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Human Anti-Insulin B Recombinant Soluble TCR (clone 6.H9) (scTCR-0565YC-S(P))
- Species Reactivity: Human
- Epitope: SHLVEALYLVCGEEG
- MHC: HLA-DQB1*03:02
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Mouse Anti-Insulin B Recombinant Soluble TCR (clone 8-1.1) (scTCR-0566YC-S(P))
- Epitope: HLVERLYLVCGGE
- MHC: H2-IA^g7
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Mouse Anti-Insulin B Recombinant Soluble TCR (clone 8F10) (scTCR-0567YC-S(P))
- Epitope: HLVERLYLVCGGE
- MHC: H2-IA^g7
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Mouse Anti-Insulin B Recombinant Soluble TCR (clone I.29) (scTCR-0568YC-S(P))
- Epitope: HLVERLYLVCGEE
- MHC: H2-IA^g7
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Mouse Anti-Insulin B Recombinant Soluble TCR (clone (PCR10.1)-1) (scTCR-0569YC-S(P))
- Epitope: HLVERLYLVCGEE
- MHC: H2-IA^g7
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Recombinant Human Anti-Insulin B Soluble TCR (T1D-4) (KIH) (VS-0622-YF7290)
- Epitope: HLVEELYLVAGEEGC (α72)
- MHC: HLA-DQ8
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Recombinant Mouse Anti-Insulin B Soluble TCR (KIH) (VS-0622-YF7283) (VS-0622-YF7283)
- Epitope: HLVERLYLVCGGE
- MHC: H2-IA^g7
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Recombinant Mouse Anti-Insulin B Soluble TCR (KIH) (VS-0622-YF7284) (VS-0622-YF7284)
- Epitope: HLVERLYLVCGGE
- MHC: H2-IA^g7
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Recombinant Mouse Anti-Insulin B Soluble TCR (KIH) (VS-0622-YF7285) (VS-0622-YF7285)
- Epitope: HLVERLYLVCGEE
- MHC: H2-IA^g7
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Recombinant Mouse Anti-Insulin B Soluble TCR (PCR10.1) (KIH) (VS-0622-YF7286)
- Epitope: HLVERLYLVCGEE
- MHC: H2-IA^g7
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Recombinant Human Anti-Insulin B Soluble TCR (T1D-10) (KIH) (VS-0622-YF7288)
- Epitope: HLVEELYLVAGEEGC (α72)
- MHC: HLA-DQ8
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Recombinant Human Anti-Insulin B Soluble TCR (T1D-3) (KIH) (VS-0622-YF7289)
- Epitope: HLVEELYLVAGEEGC (α72)
- MHC: HLA-DQ8
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Recombinant Mouse Anti-Insulin B Soluble TCR (PCR10.1) (C-Cys) (VS-0622-YF4578)
- Epitope: HLVERLYLVCGEE
- MHC: H2-IA^g7
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Recombinant Human Anti-Insulin B Soluble TCR (T1D-10) (C-Cys) (VS-0622-YF4580)
- Epitope: HLVEELYLVAGEEGC (α72)
- MHC: HLA-DQ8
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Recombinant Human Anti-Insulin B Soluble TCR (T1D-3) (C-Cys) (VS-0622-YF4581)
- Epitope: HLVEELYLVAGEEGC (α72)
- MHC: HLA-DQ8
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Recombinant Human Anti-Insulin B Soluble TCR (T1D-4) (C-Cys) (VS-0622-YF4582)
- Epitope: HLVEELYLVAGEEGC (α72)
- MHC: HLA-DQ8
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Recombinant Human Anti-Insulin B Soluble TCR (20D11) (KIH) (VS-0622-YF7281)
- Epitope: SHLVEALYLVCGEEG
- MHC: HLA-DQA1*03:01/DQB1*03:02
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Recombinant Human Anti-Insulin B Soluble TCR (6.H9) (KIH) (VS-0622-YF7282)
- Species Reactivity: Human
- Epitope: SHLVEALYLVCGEEG
- MHC: HLA-DQB1*03:02
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Recombinant Human Anti-Insulin B Soluble TCR (T1D-4) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1874)
- Epitope: HLVEELYLVAGEEGC (α72)
- MHC: HLA-DQ8
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Recombinant Human Anti-Insulin B Soluble TCR (20D11) (C-Cys) (VS-0622-YF4573)
- Epitope: SHLVEALYLVCGEEG
- MHC: HLA-DQA1*03:01/DQB1*03:02
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Recombinant Human Anti-Insulin B Soluble TCR (6.H9) (C-Cys) (VS-0622-YF4574)
- Species Reactivity: Human
- Epitope: SHLVEALYLVCGEEG
- MHC: HLA-DQB1*03:02
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Recombinant Mouse Anti-Insulin B Soluble TCR (C-Cys) (VS-0622-YF4575) (VS-0622-YF4575)
- Epitope: HLVERLYLVCGGE
- MHC: H2-IA^g7
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Recombinant Mouse Anti-Insulin B Soluble TCR (C-Cys) (VS-0622-YF4576) (VS-0622-YF4576)
- Epitope: HLVERLYLVCGGE
- MHC: H2-IA^g7
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Recombinant Mouse Anti-Insulin B Soluble TCR (C-Cys) (VS-0622-YF4577) (VS-0622-YF4577)
- Epitope: HLVERLYLVCGEE
- MHC: H2-IA^g7
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Recombinant Mouse Anti-Insulin B Soluble TCR (ZIP-Fos/ZIP-Jun) (VS-0622-YF1867) (VS-0622-YF1867)
- Epitope: HLVERLYLVCGGE
- MHC: H2-IA^g7
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Recombinant Mouse Anti-Insulin B Soluble TCR (ZIP-Fos/ZIP-Jun) (VS-0622-YF1868) (VS-0622-YF1868)
- Epitope: HLVERLYLVCGGE
- MHC: H2-IA^g7
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Recombinant Mouse Anti-Insulin B Soluble TCR (ZIP-Fos/ZIP-Jun) (VS-0622-YF1869) (VS-0622-YF1869)
- Epitope: HLVERLYLVCGEE
- MHC: H2-IA^g7
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Recombinant Mouse Anti-Insulin B Soluble TCR (PCR10.1) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1870)
- Epitope: HLVERLYLVCGEE
- MHC: H2-IA^g7
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Recombinant Human Anti-Insulin B Soluble TCR (T1D-10) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1872)
- Epitope: HLVEELYLVAGEEGC (α72)
- MHC: HLA-DQ8
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Recombinant Human Anti-Insulin B Soluble TCR (T1D-3) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1873)
- Epitope: HLVEELYLVAGEEGC (α72)
- MHC: HLA-DQ8
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Mouse Anti-Insulin B Recombinant Soluble TCR (clone (PCR10.1)-2) (scTCR-0570YC-S(P))
- Epitope: HLVERLYLVCGGE
- MHC: H2-IA^g7
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Human Anti-Insulin B Recombinant Soluble TCR (clone T1D-10) (scTCR-0571YC-S(P))
- Epitope: HLVEELYLVAGEEGC (α72)
- MHC: HLA-DQ8
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Human Anti-Insulin B Recombinant Soluble TCR (clone T1D-3) (scTCR-0572YC-S(P))
- Epitope: HLVEELYLVAGEEGC (α72)
- MHC: HLA-DQ8
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Human Anti-Insulin B Recombinant Soluble TCR (clone T1D-4) (scTCR-0573YC-S(P))
- Epitope: HLVEELYLVAGEEGC (α72)
- MHC: HLA-DQ8
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Recombinant Human Anti-Insulin B Soluble TCR (20D11) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1865)
- Epitope: SHLVEALYLVCGEEG
- MHC: HLA-DQA1*03:01/DQB1*03:02
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Recombinant Human Anti-Insulin B Soluble TCR (6.H9) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1866)
- Species Reactivity: Human
- Epitope: SHLVEALYLVCGEEG
- MHC: HLA-DQB1*03:02
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For Research Use Only. Not For Clinical Use.

Background

A polymorphism at β57 in some major histocompatibility complex class II (MHCII) alleles of rodents and humans is associated with a high risk for developing type 1 diabetes (T1D). However, a highly diabetogenic insulin B chain epitope within the B:9–23 peptide is presented poorly by these alleles to a variety of mouse and human CD4 T cells isolated from either nonobese diabetic (NOD) mice or humans with T1D.