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KCNE4
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For Research Use Only. Not For Clinical Use.
Background
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Smooth muscle cells, Sertoli cells, Fibroblasts, Melanocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (AN3-CA)
Interaction
Interacts with KCNQ1; impairs KCNQ1 localization in lipid rafts and inhibits voltage-gated potassium channel activity.
Molecular function
Ion channel, Potassium channel, Voltage-gated channel
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