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KIF20A

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For Research Use Only. Not For Clinical Use.


Background

Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Erythroid cells, Spermatocytes, Extravillous trophoblasts, Granulosa cells, Cytotrophoblasts)

Immune cell specificity

Group enriched (NK-cell, T-reg)

Cell line specificity

Low cell line specificity

Molecular function

Motor protein

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