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KYNU

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For Research Use Only. Not For Clinical Use.


Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Protein class

Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (monocytes, Langerhans cells, Basal respiratory cells, Macrophages, Ionocytes, Club cells, Syncytiotrophoblasts)

Immune cell specificity

Group enriched (intermediate monocyte, non-classical monocyte, myeloid DC, classical monocyte, plasmacytoid DC, memory B-cell, naive B-cell)

Cell line specificity

Cell line enhanced

Interaction

Homodimer.

Molecular function

Hydrolase

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