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LDLRAP1
Loading...Anti-LDLRAP1 Products
- Recombinant Mouse Anti-Human LDLRAP1 Antibody (MOB-0701MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC, IF, WB
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- Anti-Mouse LDLRAP1 Immunohistochemistry Kit (VS-0525-XY3977)
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- Species Reactivity: Human, Mouse, Rat
- Target: LDLRAP1
- Application: IHC
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- Anti-LDLRAP1 Immunohistochemistry Kit (VS-0525-XY3976)
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- Species Reactivity: Human
- Target: LDLRAP1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Horizontal cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts (via PID domain) with LDLR (via NPXY motif) (PubMed:12221107). Binds to soluble clathrin trimers (PubMed:12221107). Interacts with AP2B1; the interaction mediates the association with the AP-2 complex (PubMed:12221107). Interacts with VLDLR (By similarity). Interacts with LRP2 (By similarity).
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