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LGALS3
Loading...Anti-LGALS3 ProductsBackground
Anti-LGALS3 Products
- AbPlus™ Anti-LGALS3 Magnetic Beads (CBL229) (VS-0424-XY171)
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- Target: LGALS3
- Target Species: Human
- Application: IP, Protein Purification
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- AbPlus™ Anti-LGALS3 Magnetic Beads (VS-0724-YC1497) (VS-0724-YC1497)
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- Target: LGALS3
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
Background
LGALS3 encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi.
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Distal enterocytes, Paneth cells)
Immune cell specificity
Group enriched (classical monocyte, intermediate monocyte, non-classical monocyte, myeloid DC, T-reg)
Cell line specificity
Cell line enhanced (ASC TERT1, CAPAN-2, OE19, SK-MEL-30)
Interaction
Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Interacts with CD6 and ALCAM (PubMed:24945728). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA. Interacts with TRIM16; this interaction mediates autophagy of damage endomembranes. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion (PubMed:32272059).
Molecular function
IgE-binding protein
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