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LHB
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Syncytiotrophoblasts, Pancreatic endocrine cells, Late spermatids, Early spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (A549, HEK93, Hep G2, K-562, U-266/84)
Interaction
Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
Molecular function
Hormone
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC
-
- Derivation: Phage display library screening
- Species Reactivity: Human, Predicted to work with: Cow
- Type: IgG
- Application: IHC-P
- Lutropin alfa (TP-036CL)
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- CAS number: 152923-57-4
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For Research Use Only. Not For Clinical Use.