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LIFR

Anti-LIFR Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo.
Protein class

Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Hepatic stellate cells, Astrocytes, Adipocytes, Endothelial cells, Oligodendrocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AF22, HHSteC, SCLC-21H)

Interaction

Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR.

Molecular function

Receptor

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