Anti-M6PR Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs offers a wide variety of research-grade, highly specific anti-M6PR recombinant antibodies for your cell biology and lysosomal disease projects. The Cation-Dependent Mannose-6-Phosphate Receptor (M6PR) is the major receptor that traffics lysosomal enzymes to lysosomes, and as such it plays a critical role in lysosomal biogenesis. Creative Biolabs' top-quality anti-M6PR antibodies are powerful tools for studying protein trafficking in normal cells and understanding the molecular pathogenesis of lysosomal storage diseases.

M6PR: The Trafficker of Lysosomal Enzymes

The Cation-Dependent Mannose-6-Phosphate Receptor (M6PR), also known as CD-M6PR, is a transmembrane receptor that shuttles from the trans-Golgi network (TGN) to endosomes. M6PR binds newly synthesized lysosomal enzymes that have been tagged with a mannose-6-phosphate (M6P) signal in the Golgi. M6PR binds the enzyme in the TGN and then traffics it via clathrin coated vesicles to endosomes. Once in the endosome, the enzyme dissociates from the receptor due to the low pH and the receptor is recycled back to the TGN for another round of trafficking. This M6PR-mediated trafficking is the major pathway for lysosomes to be populated with the correct hydrolases.

Alternative Names

M6PR; Cation-Dependent Mannose-6-Phosphate Receptor; MPR46; Mr 46,000 Man6PR; 46 KDa Mannose 6-Phosphate Receptor; MPR 46; Mannose-6-Phosphate Receptor (Cation Dependent); MPR-46; SMPR; 46-KDa Mannose 6-Phosphate Receptor; CD Man-6-P Receptor; MPRD; CD-MP

Background

This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.

Anti-M6PR rAb Products

Our anti-M6PR recombinant antibodies (rAbs) are designed to have the highest specificity possible. They are thoroughly validated to recognize M6PR without cross-reactivity to the larger cation-independent M6P receptor, also known as IGF2R. We've optimized these antibodies for applications like immunofluorescence to study its canonical TGN/endosomal localization or Western Blot. In either case, you can expect clean and unambiguous signals for your work.

Table 1. Featured anti-M6PR recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs' rAb platform is designed for areas of specialization in cell biology. Our anti-M6PR recombinant antibodies are expressed in systems that have been optimized for the production of active and highly specific antibodies that recognize the native receptor with high fidelity, so you can be sure your work will be done with the best.

Featured Anti-M6PR Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-M6PR recombinant antibody production.

Fig.2 Gram-scale anti-M6PR recombinant antibody production.

rAb Modalities

Creative Biolabs is proud to further your scientific progress with a range of flexible modalities. Our anti-M6PR recombinant antibodies are available in many formats to give you a range of tools for your cell biology projects so researchers across the globe can learn more about this important trafficking receptor.

Fig.3 Full-length anti-M6PR recombinant antibody production and modalities.

Unlock the important functions of M6PR in protein trafficking with Creative Biolabs recombinant antibodies. Our anti-M6PR antibodies are characterized by high specificity and extensive validation and represent the ideal tools for your research needs. Collaborate with us for quality that powers discovery. Reach out to our experts today.