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MEIS2

Anti-MEIS2 Products

Rabbit Anti-MEIS2 Recombinant Antibody (clone JB40-38) (VS3-WK297)
- Derivation: Rabbit
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, ELISA
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Recombinant Rabbit Anti-MEIS2 Monoclonal Antibody (JB40-38) (MRO-0977-CN)
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, FC
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Recombinant Mouse Anti-Human MEIS2 Antibody (MOB-1425MZ)
- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P, WB
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Anti-MEIS2 Immunohistochemistry Kit (VS-0525-XY4346)
- Species Reactivity: Human
- Target: MEIS2
- Application: IHC
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Hi-Affi™ Recombinant Rabbit Anti-MEIS2 Monoclonal Antibody (DS2209AB) (MOR-2209)
- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB, FC
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For Research Use Only. Not For Clinical Use.

Background

This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.

Protein class

Disease related genes, Human disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Astrocytes, Oligodendrocyte precursor cells, Cone photoreceptor cells, Oligodendrocytes, Hepatic stellate cells, Excitatory neurons)

Immune cell specificity

Group enriched (basophil, eosinophil)

Cell line specificity

Cell line enhanced (fHDF/TERT166, SH-SY5Y)

Interaction

Monomer and homodimer (PubMed:26550823). Heterodimer with HOXB13 (Ref.16). Isoform 2 interacts with TLX1. Isoform 3 interacts with HOXA13 and PBX1 isoform PBX1b. Isoform 4 interacts with SP1, SP3 and KLF4. Isoform 4 and isoform 5 interact with PBX1 isoform PBX1a; the interaction partially relieves MEIS2 autoinhibition. Isoform 3 also known as MEIS2b is part of a PDX1:PBX1b:Meis2B complex; Meis2B is recruited by PBX1b and can be replaced by isoform 4 in a small fraction of complexes. Can form trimeric complexes including HOXB8 and PBX2 or PBX3.

Molecular function

Activator, Developmental protein, DNA-binding

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