Newcastle disease is caused by a virus of avian Newcastle disease acute, highly contagious and fatal diseases, harm to our country and the world poultry industry and its grave, was identified as the Office International des Epizooties Class A infectious disease, is also China's poultry one of the important disease quarantine of export meat. For viral diseases, there is currently no specific treatment. Single-chain antibodies genetically engineered antibody, with its unique advantages antiviral activity and can be prepared in large-scale engineering, it shows great potential for the development of antiviral drugs, being in this area a high priority.