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NME8
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.[provided by RefSeq, Nov 2009]
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Spermatocytes, Late spermatids, dendritic cells, NK-cells, Oligodendrocytes)
Immune cell specificity
Immune cell enhanced (plasmacytoid DC)
Cell line specificity
Cell line enhanced (HMC-1, NB-4, NTERA-2, THP-1, U-937)
Interaction
Monomer.
Molecular function
Developmental protein
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