+ Filter

NR4A3

Anti-NR4A3 Products

Mouse Anti-NR4A3 Recombinant Antibody (clone 30A4) (MOB-3732z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
Compare

Recombinant Mouse anti-Human NR4A3 Monoclonal antibody (EML783) (MOB-0797CT)
- Species Reactivity: Human
- Application: ICC/IF, WB
Compare

Anti-NR4A3 Immunohistochemistry Kit (VS-0525-XY4964)
- Species Reactivity: Human
- Target: NR4A3
- Application: IHC
Compare

Anti-Mouse NR4A3 Immunohistochemistry Kit (VS-0525-XY4965)
- Species Reactivity: Human, Mouse, Rat
- Target: NR4A3
- Application: IHC
Compare

More Infomation

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

More Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene.

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Nuclear receptors, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Langerhans cells, Cardiomyocytes, Macrophages)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (BJ hTERT+, HeLa, SK-MEL-30, U-266/70)

Interaction

Interacts with SIX3 (via homeobox); differentially regulates the transcriptional activities of NR4A3 (PubMed:12543801). Interacts with the constituents of DNA-PK heterotrimer PRKDC, XRCC6 and XRCC5; phosphorylates and prevents NR4A3 ubiquitinylation and degradation (PubMed:25852083). Interacts with NCOA2; potentiates the activity of the NR4A3. Interacts with NCOA1, NCOA3, MED1 and KAT2B. Interacts with EP300 and NCOA2; mediates the recruitment of MED1 in the coactivator complex (By similarity). Interacts with NR3C1 (via nuclear receptor DNA-binding domain); the interactions represses transcription activity of NR4A3 on the POMC promoter Nur response element (NurRE). Interacts with TRIM28; the interactions potentiates NR4A3 activity on NurRE promoter. Binds DNA as a monomer and homodimer. Interacts with PARP1; activates PARP1 by improving acetylation of PARP1 and suppressing the interaction between PARP1 and SIRT1 (By similarity).

Molecular function

DNA-binding, Receptor

More Types Infomation