Plasma proteins
Secreted
Cell type enhanced (Proximal enterocytes)
Low immune cell specificity
Low cell line specificity
Interacts (via GBA motif) with guanine nucleotide-binding protein G(i) alpha subunits GNAI1, GNAI2 and GNAI3 with higher affinity for GNAI1 and GNAI3 than for GNAI2. Preferentially interacts with inactive rather than active GNAI3. Interaction with GNAI3 is inhibited when NUCB1 binds calcium, probably due to a conformational change which renders the GBA motif inaccessible.
DNA-binding, Guanine-nucleotide releasing factor
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For Research Use Only. Not For Clinical Use.