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NXN
Anti-NXN Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).
Protein class
Disease related genes, Enzymes, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Microglial cells, Urothelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HaCaT, HHSteC)
Interaction
Associates with the phosphatase 2A holoenzyme. Interacts with PPP2CA; the interaction is direct. Interacts with DVL1 (via PDZ domain); the interaction is direct and regulated by oxidative stress (By similarity).
Molecular function
Developmental protein, Oxidoreductase
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