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OPTC
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For Research Use Only. Not For Clinical Use.
Background
Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).
Predicted location
Secreted
Single cell type specificity
Group enriched (Oligodendrocyte precursor cells, Spermatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
Homodimer.
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