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PAPSS2
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For Research Use Only. Not For Clinical Use.
Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3-phosphoadenosine 5-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Alveolar cells type 1, Distal enterocytes, Proximal enterocytes, Hepatocytes, Theca cells)
Immune cell specificity
Group enriched (non-classical monocyte, intermediate monocyte, myeloid DC)
Cell line specificity
Cell line enhanced (BJ, fHDF/TERT166, HHSteC)
Molecular function
Kinase, Multifunctional enzyme, Nucleotidyltransferase, Transferase
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