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PARVB
Loading...Anti-PARVB Products
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- Derivation: Phage display library screening
- Species Reactivity: Mouse, Rat, Human
- Type: IgG
- Application: WB
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- Anti-PARVB Immunohistochemistry Kit (VS-0525-XY5189)
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- Species Reactivity: Human
- Target: PARVB
- Application: IHC
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- Anti-Mouse PARVB Immunohistochemistry Kit (VS-0525-XY5190)
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- Species Reactivity: Human, Mouse, Rat
- Target: PARVB
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants.
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Erythroid cells, Hofbauer cells, Macrophages)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HUVEC TERT2, RPMI-8226)
Interaction
Interacts with DYSF. Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin.
Molecular function
Actin-binding
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