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PHEX
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- Mouse Anti-PHEX Recombinant Antibody (clone 2B1) (MOB-2821z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, IHC
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets
Predicted location
Membrane
Single cell type specificity
Group enriched (Granulosa cells, dendritic cells)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Cell line enhanced (HBEC3-KT, HUVEC TERT2, PC-3, TIME, U-87 MG, WM-115)
Interaction
Interacts with MEPE; the interaction is zinc-dependent (via ASARM motif).
Molecular function
Hydrolase, Metalloprotease, Protease
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