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PIK3C2G
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Gastric mucus-secreting cells, Basal squamous epithelial cells, Collecting duct cells, Breast myoepithelial cells, Breast glandular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (BEWO, HaCaT, hTERT-HME1)
Molecular function
Kinase, Transferase
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