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PLA2G2A
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Anti-PLA2G2A Products
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.
Protein class
Enzymes, FDA approved drug targets, Metabolic proteins, RAS pathway related proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Exocrine glandular cells, Prostatic glandular cells, Undifferentiated cells, Fibroblasts, Paneth cells, Distal enterocytes, Intestinal goblet cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (Hep G2, OE19)
Molecular function
Antimicrobial, Bacteriolytic enzyme, Hydrolase
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