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PLSCR1
Loading...Anti-PLSCR1 Products
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC, WB, FC, IP
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- Anti-PLSCR1 Immunohistochemistry Kit (VS-0325-XY1680)
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- Species Reactivity: Human, Mouse, Rat
- Target: PLSCR1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a phospholipid scramblase family member. The encoded protein is involved in disruption of the asymmetrical distribution of phospholipids between the inner and outer leaflets of the plasma membrane, resulting in externalization of phosphatidylserine. This cell membrane disruption plays an important role in the blood coagulation cascade as well as macrophage clearing of apoptotic cells.
Protein class
Transporters
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Ductal cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, HHSteC, SK-MEL-30)
Interaction
Forms homooligomers in the presence of calcium (PubMed:24648509). Interacts with ABL (PubMed:11390389). Interacts with RELT, RELL1 and RELL2 (PubMed:22052202). Interacts with OXSR1 in the presence of RELT (PubMed:22052202). Interacts with TOP2A and TOP2B (PubMed:17567603). Interacts with OCLN (PubMed:21806988). Interacts with TRPC5 (PubMed:32110987). Interacts with TRPC1 and TRPC4 (By similarity). (Microbial infection) Interacts with hepatitis C virus E1 and E2 glycoproteins.
Molecular function
DNA-binding, Host cell receptor for virus entry, Hydrolase, Nuclease, Receptor
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