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PML-RAR
Loading...Anti-PML-RAR Products
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- Class: Class II
- Antigen: PML-RAR
- Antigen Species: Human
- Peptide: LSSCITQGKAIETQSSSSEE
- Conjugate: PE
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- Recombinant Mouse Anti-Human PML-RAR Antibody (PG-M3) (EPAF-0365LC)
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- Species Reactivity: Human
- Type: IgG1
- Application: WB
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For Research Use Only. Not For Clinical Use.
Promyelocytic leukemia protein (PML) is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of nuclear structures, called PML-nuclear bodies, which form amongst the chromatin of the cell nucleus. These nuclear bodies are present in mammalian nuclei, at about 1 to 30 per cell nucleus. The retinoic acid receptor (RAR) is a type of nuclear receptor which can also act as a transcription factor that is activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma, encoded by the RARA, RARB, RARG genes, respectively. Each receptor isoform has ten splice variants: four for alpha, four for beta, and two for gamma.