


PRKX

Anti-PRKX Products
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, ICC, FC
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For Research Use Only. Not For Clinical Use.
Background
Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets
Intracellular
Cell type enhanced (Glandular and luminal cells, Endometrial ciliated cells, NK-cells, dendritic cells)
Immune cell enhanced (basophil)
Cell line enhanced (HMC-1)
Like other cAMP-dependent protein kinases, the inactive holoenzyme is probably composed of 2 PRKX catalytic subunits and a dimer of regulatory subunits. Interacts (cAMP-dependent) specifically with the regulatory subunits PRKAR1A and PRKAR1B. Compared to other cAMP-dependent serine/threonine protein kinases, does not interact with the 2 other PKA regulatory subunits PRKAR2A and PRKAR2B. Interacts with cAMP-dependent protein kinase inhibitor/PKI proteins; inhibits PRKX. Interacts with GPKOW. Interacts with SMAD6. Interacts with PKD1; involved in differentiation and controlled morphogenesis of the kidney. Interacts with PIN1 (via WW domain).
Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase