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PRSS16

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For Research Use Only. Not For Clinical Use.


This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region.
Protein class

Enzymes

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Cytotrophoblasts, Syncytiotrophoblasts, Extravillous trophoblasts)

Immune cell specificity

Immune cell enhanced (memory B-cell)

Cell line specificity

Cell line enhanced (hTCEpi, RPMI-8226)

Molecular function

Hydrolase, Protease, Serine protease

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