Enzymes, Plasma proteins
Intracellular
Low cell type specificity
Low immune cell specificity
Low cell line specificity
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 34711951). The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 34711951). The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 34711951). The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7 (PubMed:25599644, 26133119, 27342858, 27428775, 27493187, 34711951). PSMA7 interacts directly with the PSMG1-PSMG2 heterodimer which promotes 20S proteasome assembly (PubMed:16251969). Interacts with HIF1A (PubMed:11389899). Interacts with RAB7A (PubMed:14998988). Interacts with PRKN (PubMed:15987638). Interacts with ABL1 and ABL2 (PubMed:16678104). Interacts with EMAP2 (PubMed:19362550). Interacts with MAVS (PubMed:19734229). (Microbial infection) Interacts with HIV-1 TAT protein. (Microbial infection) Interacts with hepatitis B virus X protein (HBX).
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For Research Use Only. Not For Clinical Use.