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PTAFR
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
Protein class
FDA approved drug targets, G-protein coupled receptors, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Kupffer cells, Pancreatic endocrine cells, granulocytes, Hofbauer cells, Langerhans cells, Macrophages, monocytes)
Immune cell specificity
Group enriched (eosinophil, neutrophil, classical monocyte)
Cell line specificity
Group enriched (HBEC3-KT, HMC-1)
Interaction
Interacts with ARRB1.
Molecular function
G-protein coupled receptor, Receptor, Transducer
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