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RAB10
Loading...Anti-RAB10 Products
- Mouse Anti-RAB10 Recombinant Antibody (clone 4E2) (VS3-XY1343)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, ICC
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- Derivation: Phage display library screening
- Species Reactivity: Mouse
- Type: IgG
- Application: WB
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- Mouse Anti-RAB10 Monoclonal Antibody (VS7-0425-WR731) (VS7-0425-WR731)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB, IF, ICC, ELISA
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- Anti-RAB10 Immunohistochemistry Kit (VS-0325-XY1839)
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- Species Reactivity: Human, Mouse, Rat
- Target: RAB10
- Application: IHC
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For Research Use Only. Not For Clinical Use.
RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).
Protein class
Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Suprabasal keratinocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with MYO5A; mediates the transport to the plasma membrane of SLC2A4/GLUT4 storage vesicles (PubMed:22908308). Interacts with GDI1 and with GDI2; negatively regulates RAB10 association with membranes and activation (PubMed:19570034, PubMed:26824392, PubMed:29125462). Interacts (GDP-bound form) with LLGL1; the interaction is direct and promotes RAB10 association with membranes and activation through competition with the Rab inhibitor GDI1 (By similarity). Interacts with EXOC4; probably associates with the exocyst (By similarity). Interacts (GTP-bound form) with MICALCL, MICAL1, MICAL3, EHBP1 and EHBP1L1; at least in case of MICAL1 two molecules of RAB10 can bind to one molecule of MICAL1 (PubMed:27552051). Interacts with TBC1D13 (By similarity). Interacts with SEC16A (By similarity). Interacts with CHM and CHML (PubMed:29125462). Interacts with LRRK2; interaction facilitates phosphorylation of Thr-73 (PubMed:26824392). Interacts (when phosphorylated on Thr-73) with RILPL1 and RILPL2 (PubMed:30398148, PubMed:29125462). Interacts with TBC1D21 (PubMed:28067790).
Molecular function
Hydrolase
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