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RAD54B
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Oligodendrocyte precursor cells, Astrocytes, Cone photoreceptor cells, Oligodendrocytes, Inhibitory neurons)
Immune cell specificity
Immune cell enhanced (MAIT T-cell)
Cell line specificity
Low cell line specificity
Interaction
Interacts with RAD51 through the NH2-terminal domain. Immunoprecipitation experiments show that the interaction is constitutive and not induced by ionizing radiation. The interaction may be indirect.
Molecular function
DNA-binding, Helicase, Hydrolase
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