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RARRES3
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For Research Use Only. Not For Clinical Use.
Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator. [provided by RefSeq, Jul 2008]
Protein class
Enzymes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (dendritic cells, Syncytiotrophoblasts, Hofbauer cells, Cytotrophoblasts, Extravillous trophoblasts, T-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (CAPAN-2, RPTEC TERT1, SK-BR-3, U-266/70)
Interaction
Interacts with TGM1.
Molecular function
Hydrolase, Transferase
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