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RELN

Anti-RELN Products
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IHC
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- Derivation: Rabbit
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, IHC
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- Species Reactivity: Mouse
- Application: IHC(PFAfixed), WB
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- Derivation: Phage display library screening
- Species Reactivity: Rat, Does not react with Mouse
- Type: IgG
- Application: WB
- Anti-RELN Immunohistochemistry Kit (VS-0525-XY6076)
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- Species Reactivity: Human
- Target: RELN
- Application: IHC
- Anti-Mouse RELN Immunohistochemistry Kit (VS-0525-XY6077)
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- Species Reactivity: Human, Mouse, Rat
- Target: RELN
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Group enriched (Inhibitory neurons, Hepatic stellate cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (Hep G2, PC-3, SCLC-21H, SH-SY5Y, TIME)
Interaction
Oligomer of disulfide-linked homodimers. Binds to the ectodomains of VLDLR and LRP8/APOER2 (By similarity).
Molecular function
Developmental protein, Hydrolase, Protease, Serine protease
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