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RGS14
Loading...Anti-RGS14 Products
- Mouse Anti-Rgs14 Recombinant Antibody (VS-0522-LC17) (VS-0522-LC17)
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- Species Reactivity: Rat
- Type: Mouse IgG2a
- Application: WB, IHC
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- Rat Anti-Rgs14 Recombinant Antibody (VS-0522-LC18) (VS-0522-LC18)
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- Species Reactivity: Rat
- Type: Rat IgG2b
- Application: WB, IHC
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- Rabbit Anti-Rgs14 Recombinant Antibody (VS-0522-LC19) (VS-0522-LC19)
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- Species Reactivity: Rat
- Type: Rabbit IgG
- Application: WB, IHC
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- Anti-RGS14 Immunohistochemistry Kit (VS-0325-XY1911)
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- Species Reactivity: Human, Mouse, Rat
- Target: RGS14
- Application: IHC
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- Chicken Anti-RGS14 Polyclonal IgY (BRD-0497MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.
Background
RGS14 (Regulator Of G Protein Signaling 14) is a Protein Coding gene. This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. Among its related pathways are Peptide ligand-binding receptors and Development Beta-adrenergic receptors regulation of ERK.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Suprabasal keratinocytes, Proximal tubular cells, Squamous epithelial cells, Basal squamous epithelial cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HDLM-2, HMC-1, NB-4, RPMI-8226)
Interaction
Interacts with GNAO1, GNAI2 and GNAI3 (By similarity). Interacts with GNAI1 (PubMed:18434541, PubMed:21115486). Interacts (via RGS and GoLoco domains) with GNAI1; the interaction occurs in the centrosomes. Interaction with GNAI1 or GNAI3 (via active GTP- or inactive GDP-bound forms) prevents association of RGS14 with centrosomes or nuclear localization (By similarity). Interacts with RABGEF1; the interactions is GTP-dependent. Interacts with RAP2A; the interactions is GTP-dependent and does not alter its function on G(i) alpha subunits either as GAP or as GDI (By similarity). Associates with microtubules (PubMed:15917656). Found in a complex with at least BRAF, HRAS, MAP2K1, MAPK3 and RGS14. Interacts with RIC8A (via C-terminus). Interacts (via RBD 1 domain) with HRAS (active GTP-bound form preferentially). Interacts (via RBD domains) with BRAF (via N-terminus); the interaction mediates the formation of a ternary complex with RAF1. Interacts (via RBD domains) with RAF1 (via N-terminus); the interaction mediates the formation of a ternary complex with BRAF. Interacts with KRAS (active GTP-bound form preferentially), MRAS (active GTP-bound form preferentially), NRAS (active GTP-bound form preferentially) and RRAS (active GTP-bound form preferentially).
Molecular function
GTPase activation, Signal transduction inhibitor
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