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SCARF1
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Adipocytes, Hepatic stellate cells, Endothelial cells, Langerhans cells, Microglial cells)
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Group enriched (HUVEC TERT2, REH, TIME)
Interaction
Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL. Interacts with AVIL (By similarity).
Molecular function
Receptor
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