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SCGB1A1

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For Research Use Only. Not For Clinical Use.


This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma.
Protein class

Cancer-related genes, Plasma proteins

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enriched (Club cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (HaCaT)

Interaction

Antiparallel homodimer; disulfide-linked (PubMed:7664082). Interaction with LMBR1L has been observed in PubMed:16423471, but not in PubMed:23964685 (PubMed:16423471, PubMed:23964685).

Molecular function

Phospholipase A2 inhibitor

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