SDC1
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- Derivation: Chimeric (mouse/Human)
- Species Reactivity: Human
- Type: Chimeric (mouse/Human) IgG4, κ
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
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- Anti-Human SDC1 Recombinant Antibody (TAB-552CL)
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- Species Reactivity: Human
- Type: Antibody
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- Mouse Anti-SDC1 Recombinant Antibody (TAB-495CT) (TAB-495CT)
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: FC, WB
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- Mouse Anti-SDC1 Recombinant Antibody; scFv Fragment (TAB-495CT-S(P)) (TAB-495CT-S(P))
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC, WB
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- Mouse Anti-SDC1 Recombinant Antibody; Fab Fragment (TAB-495CT-F(E)) (TAB-495CT-F(E))
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- Derivation: Mouse hybridoma cell line
- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC, WB
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
Syndecan-1 (SDC1), or CD138, is a transmembrane proteoglycan expressed on plasma cells, epithelial cells, and stromal cells. It binds growth factors, chemokines, and extracellular matrix molecules, regulating cell adhesion, signaling, and angiogenesis. CD138 is highly expressed on malignant plasma cells in multiple myeloma (MM) and is a diagnostic marker for the disease. It is targeted by monoclonal antibodies (elotuzumab) and ADCs, which induce ADCC and inhibit signaling pathways critical for MM cell survival. CD138 targeting is integral to MM treatment, particularly in combination with other agents like proteasome inhibitors.
Protein class
Cancer-related genes, CD markers, Metabolic proteins, Plasma proteins, Transporters
Predicted location
Intracellular, Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Hepatocytes, Urothelial cells, Cholangiocytes, Syncytiotrophoblasts, Squamous epithelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HBEC3-KT, hTCEpi, U-251 MG, U-266/70, U-266/84)
Interaction
Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain). Interacts with MDK (By similarity).
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