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SH2B3

Anti-SH2B3 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC, ICC, IF, IHC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
- Anti-SH2B3 Immunohistochemistry Kit (VS-0525-XY6546)
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- Species Reactivity: Human
- Target: SH2B3
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Langerhans cells, Kupffer cells, Macrophages, monocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced
Interaction
Binds to the tyrosine-phosphorylated TCR zeta chain via its SH2 domain.
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