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SKAP1
Loading...Anti-SKAP1 Products
- Recombinant Mouse Anti-Human SKAP1 Antibody (MOB-1781MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Anti-SKAP1 Immunohistochemistry Kit (VS-0525-XY6611)
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- Species Reactivity: Human
- Target: SKAP1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (NK-cells, Late spermatids, T-cells, granulocytes, dendritic cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (CAPAN-2, HDLM-2, HMC-1, JURKAT, Karpas-707, RPMI-8226, RPTEC TERT1, U-266/70, U-266/84)
Interaction
Homodimer (PubMed:9195899). Interacts with FYN (PubMed:9195899). Interacts with PTPRC (PubMed:11909961). Interacts with GRB2 when phosphorylated on Tyr-271 (PubMed:12171928). Interacts with FYB1, which is required for SKAP2 protein stability (PubMed:9748251, PubMed:9671755, PubMed:10856234, PubMed:15849195, PubMed:16461356, PubMed:27335501). Part of a complex consisting of SKAP1, FYB1 and CLNK (By similarity). Interacts with RASGRP1 (PubMed:17658605). Interacts with FYB2 (PubMed:27335501).
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