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SLC15A2

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For Research Use Only. Not For Clinical Use.


Background

The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1, the proton-coupled peptide transporter found in the small intestine.
Protein class

Metabolic proteins, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Astrocytes, Alveolar cells type 1, Club cells, Muller glia cells, Microglial cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (NB-4, U-937)

Interaction

Interacts (via extracellular domain region) with trypsin.

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