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SLINGSHOT-1L
Loading...Anti-SLINGSHOT-1L Products
- Mouse Anti-SLINGSHOT-1L Recombinant Antibody (clone 6C11G9) (VS7-0425-WR872)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC, FC
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- Mouse Anti-SLINGSHOT-1L Recombinant Antibody (clone 1A5C8) (VS7-0425-WR873)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ICC, FC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]