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SLURP1

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For Research Use Only. Not For Clinical Use.


Background

Secreted mammalian leukocyte antigen 6/urokinase-type plasminogen activator receptor-related protein-1 (SLURP1) is a Ly-6 protein superfamily molecule. It can specifically activate a7 nAChR as an endogenous ligand, and then participate in processes such as transmembrane signal transduction, cell activation and cell adhesion. The SLURP1 protein was first purified from human blood or urine peptide libraries by Adermann et al. and its specific structure was studied. French scholar Fischer et al. first reported that human SLURP1 gene mutation can trigger a rare congenital genetic disease-congenital palmoplantar keratosis. In recent years, SLURP1 has gradually become a hot spot for scholars. Recent studies have confirmed that SLURP1 is a specific allosteric ligand of a7 nAChR, which specifically binds to a7 nAChR in the environment to make it allosteric and enhance the influx of Ca2+.
Protein class

Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters

Predicted location

Secreted

Single cell type specificity

Group enriched (Suprabasal keratinocytes, Squamous epithelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HaCaT, MCF7, RT4, T-47d)

Interaction

Homodimer. Interacts with PLAU (PubMed:25168896). Interacts with CHRNA7 (PubMed:26905431).

Molecular function

Cytokine

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