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SUMO4
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For Research Use Only. Not For Clinical Use.
Background
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.
Protein class
Disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cardiomyocytes, Glandular and luminal cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HeLa)
Interaction
Interacts with SAE2. Covalently attached to a number of proteins (Probable).
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