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For Research Use Only. Not For Clinical Use.


Background

S-layer protein is a protein component on the surfaces of archaea and certain bacteria. In lactic acid bacteria, only S- layer proteins have been confirmed outside the cell wall of lactobacillusThe s-layer protein of lactobacillus lactobacillus is composed of proteins or glycoproteins subunits, which are arranged in regular crystalline arrangement. S-layer protein can completely cover the solid surface layer of the cell surface, with a thickness of 5 ~ 15 nm and a molecular weight of 40 ~ 200 k D, accounting for 10% ~ 15% of the total protein content of the cellDue to its adhesion, inhibition of pathogenic bacteria and non-pathogenic characteristics, the s-layer protein of lactobacillus has potential application value in oral active vaccine. However, the specific mechanism of action on the physiological function of s-laminin of lactobacillus is still unclear. Many studies have shown that lactobacillus plays a role in regulating the function of human immune system, and this regulatory effect is related to s-layer protein to some extent. Therefore, it is necessary to conduct in-depth study on the immune regulation function of s-layer protein, so as to further clarify the probiotic function of lactobacillus.
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