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TCL1A
Loading...Anti-TCL1A ProductsBackground
Anti-TCL1A Products
- Chicken Anti-TCL1A Polyclonal IgY (BRD-0576MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.
Background
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).
Protein class
Cancer-related genes, Disease related genes
Predicted location
Intracellular
Single cell type specificity
Group enriched (B-cells, dendritic cells)
Immune cell specificity
Group enriched (naive B-cell, plasmacytoid DC, memory B-cell)
Cell line specificity
Group enriched (Daudi, REH, U-698)
Interaction
Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.
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