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TCL1A
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
Protein class
Cancer-related genes, Disease related genes
Predicted location
Intracellular
Single cell type specificity
Group enriched (B-cells, dendritic cells)
Immune cell specificity
Group enriched (naive B-cell, plasmacytoid DC, memory B-cell)
Cell line specificity
Group enriched (Daudi, REH, U-698)
Interaction
Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.
More Types Infomation
- PE-A*02:01/Human TCL1A (SLLPIMWQL) MHC Tetramer (MHC-CN1427)
-
- Class: Class I
- Antigen: TCL1A
- Antigen Species: Human
- Peptide: SLLPIMWQL
- Conjugate: PE
- PE-A*02:01/Human TCL1 (LLPIMWQL) MHC Tetramer (MHC-CN0168)
-
- Class: Class I
- Antigen: TCL1
- Antigen Species: Human
- Peptide: LLPIMWQL
- Conjugate: PE
- APC-A*02:01/Human TCL1 (LLPIMWQL) MHC Tetramer (MHC-CN0167)
-
- Class: Class I
- Antigen: TCL1
- Antigen Species: Human
- Peptide: LLPIMWQL
- Conjugate: APC
- A*02:01/Human TCL1 (SLLPIMWQL) MHC Monomer (MHC-YF289)
-
- Class: Class I
- Antigen: TCL1
- Antigen Species: Human
- Peptide: SLLPIMWQL
- Conjugate: Biotin
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC, IHC-P, IP, WB
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB, FC, IHC, IP
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, ICC, IHC-P, WB
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC-P
- Mouse Anti-TCL1A Recombinant Antibody (VS3-CJ1051) (VS3-CJ1051)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC
- Chicken Anti-TCL1A Polyclonal IgY (BRD-0576MZ)
-
- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
- Mouse Anti-TCL1A Recombinant Antibody (clone 5E-3A) (VS3-QX1088)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC
- Mouse Anti-TCL1A Recombinant Antibody (clone 1A2G3) (VS3-XY1492)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FC
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
-
- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: IHC-P, IF
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For Research Use Only. Not For Clinical Use.