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TFE3
Loading...Anti-TFE3 Recombinant Antibody Products
- Chicken Anti-TFE3 Polyclonal IgY (BRD-1063MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.
This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Immune cell enhanced (neutrophil)
Cell line specificity
Low cell line specificity
Interaction
Homodimer and heterodimer; with TFEB or MITF.
Molecular function
Activator, DNA-binding
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