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TGFB2
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For Research Use Only. Not For Clinical Use.
Background
TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Astrocytes, Muller glia cells, Alveolar cells type 1)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (EFO-21, hTERT-RPE1, U-2 OS)
Interaction
Interacts with the serine proteases, HTRA1 and HTRA3 (By similarity). Interacts with ASPN (PubMed:17827158). Interacts with MFAP5 (By similarity). Latency-associated peptide: Interacts with Transforming growth factor beta-2 (TGF-beta-2) chain; interaction is non-covalent and maintains (TGF-beta-2) in a latent state (By similarity). Latency-associated peptide: Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-2 (PubMed:19651619). Latency-associated peptide: Interacts with NREP; the interaction results in a decrease in TGFB2 autoinduction (By similarity). Transforming growth factor beta-2: Homodimer; disulfide-linked (PubMed:1631557, PubMed:1641027). Transforming growth factor beta-2: Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).
Molecular function
Growth factor, Mitogen
More Types Infomation
Related Diseases
Inflammatory Bowel Diseases