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TLE1
Anti-TLE1 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
TLE1 (Transducin Like Enhancer Of Split 1) is a Protein Coding gene. Diseases associated with TLE1 include Synovium Cancer and Core Binding Factor Acute Myeloid Leukemia. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Signaling by NOTCH1. Gene Ontology (GO) annotations related to this gene include identical protein binding and transcription factor binding. An important paralog of this gene is TLE4.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Glandular and luminal cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homooligomer and heterooligomer with other family members. Binds RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif). Binds TCF7, LEF1, TCF7L1 and TCF7L2 (By similarity). Interacts with SIX3. Interacts with EFNB1. Interacts with TLE4 (By similarity). Interacts with FOXG1/BF-1; the interaction is inhibited by TLE6/GRG6 (By similarity).
Molecular function
Repressor
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